gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccine primes and expands KRAS G12V–specific CD8+ T cells, which recognize KRAS G12V peptides on MHC I of tumor cells and kill them via perforin/granzyme-mediated cytotoxicity (with CD4+ T-cell help).
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Shared neoantigen presented via HLA class I/II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06253520
disease_id_num_tar_ref
4684
drug_id_num_tar_ref
12670