gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine expands KRAS G12D–specific T cells; these CTLs recognize the KRAS G12D peptide on MHC of tumor cells and kill them via perforin/granzyme (and related) cytotoxic pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Shared KRAS driver neoepitope presented on HLA class I/II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06253520
disease_id_num_tar_ref
4684
drug_id_num_tar_ref
12671