gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes/boosts KRAS G12V–specific CD8+ T cells (and supports infused KRAS-specific TCR T cells). These CTLs recognize KRAS G12V peptide–MHC on tumor cells and kill them via perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Shared KRAS driver neoepitope presented on HLA class I/II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06253520
disease_id_num_tar_ref
4684
drug_id_num_tar_ref
12671