gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HS-20093 targets B7-H3 on tumor cells; after internalization it releases a topoisomerase I inhibitor that blocks DNA replication and induces apoptosis (with possible Fc-mediated ADCC/ADCP). Killing is determined by B7-H3 binding, not by topoisomerase I expression itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
intracellular payload target (released TOPOi)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06825624
disease_id_num_tar_ref
4686
drug_id_num_tar_ref
12675