gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 on target cells; CAR/CD3ΞΆ signaling activates T-cell cytotoxicity, leading to perforin/granzyme-mediated apoptosis (with possible Fas/FasL), augmented by IL-15-enhanced activation and persistence.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-ALL/B-NHL indication; CAR scFv binds extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06783816
disease_id_num_tar_ref
4692
drug_id_num_tar_ref
12695