gene_symbol
SIGLEC2
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD22 CAR T cells bind CD22 on target cells, triggering CAR/CD3zeta signaling and T-cell cytolysis via perforin/granzyme (and Fas-FasL) pathways; IL-15 enhances T-cell activation and persistence.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-ALL/B-NHL indication; CAR scFv binds extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06783816
disease_id_num_tar_ref
4692
drug_id_num_tar_ref
12695