gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize BCMA via the CAR, triggering CD3ΞΆ signaling and T-cell effector functions that kill BCMA+ cells via perforin/granzyme-mediated cytolysis (with supportive cytokine-mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Multiple myeloma indication; CAR scFv binds extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06783816
disease_id_num_tar_ref
4692
drug_id_num_tar_ref
12695