gene_symbol
IL15RA
hgnc_id
HGNC:5978
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR T cells kill cells expressing CD19/CD22/BCMA via CAR activation and perforin/granzyme release. IL‑15 signals through IL‑15 receptors on the CAR T cells to enhance their function; IL15RA+ cells are not directly targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Autocrine/cis or trans IL-15 signaling on CAR T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06783816
disease_id_num_tar_ref
4692
drug_id_num_tar_ref
12695