gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR T cells kill CD19/CD22/BCMA-expressing tumor cells via perforin/granzyme cytotoxicity. CD132 is part of the IL-15 receptor used for autocrine support of the CAR T cells; cells expressing CD132 are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Shared cytokine receptor subunit for IL-15 signaling on CAR T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06783816
disease_id_num_tar_ref
4692
drug_id_num_tar_ref
12695