gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize EGFRvIII on tumor cells and, upon CAR activation (CD3ζ/costimulatory), kill targets via perforin/granzyme-mediated cytolysis and apoptosis (HLA-independent).
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Deletion mutant EGFRΔ2-7 (tumor-specific neoepitope) on a receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05802693
disease_id_num_tar_ref
4705
drug_id_num_tar_ref
12726