gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CUSP06 binds CDH6 on tumor cells, is internalized, and releases exatecan, which inhibits DNA topoisomerase I, stabilizing the topo I–DNA complex and causing DNA breaks, replication arrest, and apoptosis (with potential bystander killing).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Exatecan payload inhibits TOP1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06234423
disease_id_num_tar_ref
37
drug_id_num_tar_ref
100