gene_symbol
PVRL4
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds nectin-4 on tumor cells, is internalized, and releases a cleavable topoisomerase I inhibitor that blocks DNA replication and induces apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody component of ADC binds cell-surface TAA
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06512051
disease_id_num_tar_ref
4710
drug_id_num_tar_ref
12737