gene_symbol
PIWIL1
hgnc_id
HGNC:9007
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ImmTAC binds the PIWIL1 peptide–HLA-A*02:01 complex and CD3 on T cells, forming a synapse that activates T cells to kill the bound target cell via perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A*02:01-restricted peptide–MHC complex on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06840119
disease_id_num_tar_ref
4715
drug_id_num_tar_ref
12748