gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IMC-R117C binds CD3ε on T cells to activate and redirect them against PIWIL1 peptide–HLA-A*02:01–positive tumor cells, which are killed by T-cell cytotoxic granules; CD3+ T cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Part of the TCR/CD3 complex; engagement recruits and activates T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06840119
disease_id_num_tar_ref
4715
drug_id_num_tar_ref
12748