gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD79b on B cells, is internalized, and releases MMAE, which then binds β‑tubulin (vinca site) to block microtubule polymerization, causing G2/M arrest and apoptosis. β‑tubulin expression alone is not sufficient—delivery requires CD79b targeting.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site on beta-tubulin, inhibiting polymerization; multiple beta-tubulin isoforms can be engaged
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05940051
disease_id_num_tar_ref
4716
drug_id_num_tar_ref
12754