gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on tumor cells; its Fc engages FCGR3A (CD16a) on NK cells to trigger ADCC, which kills EGFR-positive cells, not the FCGR3A-expressing effector cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement on NK cells to induce ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05775900
disease_id_num_tar_ref
4723
drug_id_num_tar_ref
12766