gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-HER2 ADC binds HER2, is internalized, and releases MMAE that disrupts microtubules, causing G2/M arrest and apoptosis (with possible bystander killing).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody (disitamab) binds cell-surface HER2 receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05904964
disease_id_num_tar_ref
4725
drug_id_num_tar_ref
12777