gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc engages CD16a on NK cells to trigger ADCC, killing CD20+ B cells. CD16a-expressing cells are effectors, not targets, and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated IgG1 Fc enhances affinity and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06351527
disease_id_num_tar_ref
4726
drug_id_num_tar_ref
12780