gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize the HLA-A2/MAGE-A4 peptide complex on target cells and kill them via CTL effector mechanisms, primarily perforin/granzyme-mediated apoptosis (and Fas–FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A*02:01-restricted peptide presented in MHC class I (pMHC) complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05601752
disease_id_num_tar_ref
4732
drug_id_num_tar_ref
12798