gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Killing requires recognition of the MAGE-A4 peptide presented by HLA-A2; engineered T cells then induce perforin/granzyme-mediated lysis. HLA-A2 expression alone is not sufficient for killing.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-specific restriction; presents the MAGE-A4 peptide recognized by the engineered TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05601752
disease_id_num_tar_ref
4732
drug_id_num_tar_ref
12798