gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds HBsAg; its Fc engages CD16a on NK cells/monocytes to drive ADCC and phagocytosis against HBsAg-bearing targets. CD16a-expressing cells act as effectors and are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCC engagement on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06668727
disease_id_num_tar_ref
4733
drug_id_num_tar_ref
12800