gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SHR-A2009 targets HER3 on tumor cells, is internalized, and releases a topoisomerase I inhibitor that binds Topo I to cause DNA breaks and apoptosis; Topo I expression alone is not the selection target.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
intracellular enzyme; ADC payload target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06649331
disease_id_num_tar_ref
417
drug_id_num_tar_ref
1177