gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-engineered T cells recognize the HPV16 E7 peptide presented by HLA-A*02:01 on tumor MHC I and kill target-positive cells via perforin/granzyme-mediated cytolysis (and Fas/FasL, cytokine-driven apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Presented on tumor cell MHC class I as an HLA-A*02:01–restricted peptide–MHC complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05686226
disease_id_num_tar_ref
4750
drug_id_num_tar_ref
12840