gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
E7 TCR-T cells require recognition of the HPV16 E7 peptide presented by HLA-A*02:01; HLA-A*02:01 alone is not sufficient. When the E7 peptide–HLA-A*02:01 complex is present, T cells kill via perforin/granzyme-mediated cytolysis and cytokine-induced apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-specific restriction element of the peptide–MHC complex recognized by the engineered TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05686226
disease_id_num_tar_ref
4750
drug_id_num_tar_ref
12840