gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Ubamatamab binds CD3 on T cells to activate and redirect them to MUC16+ tumor cells; the activated T cells kill the MUC16-expressing cells (perforin/granzyme), not the CD3+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 epsilon chain of the T-cell receptor complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06444880
disease_id_num_tar_ref
4760
drug_id_num_tar_ref
12869