gene_symbol
PVRL4
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds Nectin-4 on target cells, is internalized, and releases a cleavable topoisomerase I inhibitor payload that inhibits DNA replication, leading to cell-cycle arrest and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated cell-surface antigen targeted by the ADC antibody moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06649331
disease_id_num_tar_ref
417
drug_id_num_tar_ref
1178