gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages CD16a on NK cells via its afucosylated Fc to trigger ADCC, killing IL-5Rα+ targets. CD16a-expressing cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCC engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06024707
disease_id_num_tar_ref
4780
drug_id_num_tar_ref
12912