gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds HER2 and recruits FcγR-expressing effector cells to mediate ADCC, killing HER2+ cells; HER2 signaling blockade can also promote apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ECD subdomain IV (juxtamembrane region; trastuzumab-like epitope)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05985707
disease_id_num_tar_ref
4790
drug_id_num_tar_ref
12930