gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc engages FcγR-bearing effector cells to mediate ADCC (and some CDC/ADCP), leading to lysis/phagocytosis of EGFR-expressing cells; signaling blockade is antiproliferative rather than cytotoxic.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III); blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06547203
disease_id_num_tar_ref
4791
drug_id_num_tar_ref
12934