gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds BCMA on target cells, is internalized, and releases the microtubule inhibitor MMAF, causing G2/M arrest and apoptosis; its afucosylated Fc also enhances ADCC/ADCP against BCMA-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor on plasma cells; target of the antibody moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05847569
disease_id_num_tar_ref
4795
drug_id_num_tar_ref
12943