gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Osimertinib covalently inhibits mutant EGFR kinase (e.g., exon 19 deletion, L858R, T790M), blocking MAPK and PI3K/AKT survival signaling and inducing apoptosis of EGFR‑mutant tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Mutant-selective, irreversible covalent inhibitor binding Cys797 in the kinase domain; targets EGFR exon 19 deletions, L858R, and T790M.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06670196
disease_id_num_tar_ref
4798
drug_id_num_tar_ref
12952