gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2, is internalized, and lysosomal cleavage releases the DXd topoisomerase I inhibitor, causing DNA damage and apoptosis; trastuzumab Fc can also induce ADCC, with potential bystander killing from the membrane-permeable payload.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain binding by trastuzumab component; internalization enables DXd payload release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06386263
disease_id_num_tar_ref
42
drug_id_num_tar_ref
108