gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 on target cells and its Fc engages FcγR-expressing immune cells (e.g., NK cells), triggering antibody-dependent cellular cytotoxicity (ADCC) to kill the cells; HER2 signaling blockade can also promote apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain II (dimerization interface), blocking HER2 heterodimerization (especially with HER3); Fc can mediate ADCC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07012720
disease_id_num_tar_ref
419
drug_id_num_tar_ref
1186