gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 on target cells and induces Fc-dependent ADCC by NK cells, ADCP by macrophages, complement-dependent cytotoxicity (CDC), and can trigger apoptosis upon crosslinking.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface ectoenzyme (NADase/ADPR cyclase) expressed on tumor and immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05807048
disease_id_num_tar_ref
4810
drug_id_num_tar_ref
12990