gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab coats EGFR-expressing cells and engages Fcγ receptors on NK cells to trigger antibody-dependent cellular cytotoxicity (ADCC), with possible complement-dependent cytotoxicity (CDC); signaling blockade is mainly cytostatic.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III) to block ligand binding and receptor activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06725368
disease_id_num_tar_ref
4820
drug_id_num_tar_ref
13020