gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocks CD47–SIRPα signaling to remove the “don’t-eat-me” signal; Fc engagement of Fcγ receptors promotes macrophage-mediated phagocytosis (ADCP) of CD47+ cells and enhances antigen presentation, leading to downstream T-cell killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary intended target; decoy SIRPα ectodomain blocks CD47–SIRPα checkpoint
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05892718
disease_id_num_tar_ref
4822
drug_id_num_tar_ref
13022