gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug’s Fc engages CD64 on myeloid cells to activate them while the SIRPα domain blocks CD47 on tumor cells, leading to macrophage-mediated phagocytosis and T-cell priming. CD64+ cells are effector cells, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by IgG4 Fc to modulate myeloid effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05892718
disease_id_num_tar_ref
4822
drug_id_num_tar_ref
13022