gene_symbol
FCGR2B
hgnc_id
HGNC:3618
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HCB101 binds CD47 on tumor cells to block the CD47–SIRPα checkpoint and promote macrophage-mediated phagocytosis via Fcγ receptor engagement. CD32B is an Fcγ receptor on immune cells and is not the antigen targeted for killing; CD32B+ cells are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibitory FcγR; IgG4 Fc engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05892718
disease_id_num_tar_ref
4822
drug_id_num_tar_ref
13022