gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2 on target cells, is internalized, and releases MMAE, which inhibits tubulin polymerization causing microtubule disruption, G2/M arrest, and apoptosis (with potential bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antigen; HER2 extracellular domain binding by disitamab
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06572319
disease_id_num_tar_ref
423
drug_id_num_tar_ref
1193