gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases MMAE, which inhibits beta-tubulin polymerization causing microtubule disruption, G2/M arrest, and apoptosis; killing is determined by HER2 expression, not beta-tubulin.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca domain of beta-tubulin to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06572319
disease_id_num_tar_ref
423
drug_id_num_tar_ref
1193