gene_symbol
TERT
hgnc_id
HGNC:11730
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Peptide vaccine is taken up by APCs and presented on MHC I/II to prime hTERT-specific CD8+ (and CD4+) T cells; CTLs then recognize hTERT peptides on MHC I of telomerase-expressing cells and kill them via perforin/granzyme-mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
hTERT-derived long peptide epitope (GV1001); presented on MHC class I and II to elicit CD8+ and CD4+ T-cell responses
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06625710
disease_id_num_tar_ref
4834
drug_id_num_tar_ref
13048