gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD30 ADC binds CD30 on target cells, is internalized, the valine–citrulline linker is cleaved to release MMAE, which inhibits tubulin polymerization causing G2/M arrest and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF receptor; also used with 89Zr labeling for PET imaging in trial
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186986
disease_id_num_tar_ref
4837
drug_id_num_tar_ref
13053