gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Brentuximab vedotin binds CD30 (not beta-tubulin); after internalization into CD30+ cells, MMAE is released and binds beta-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis. Beta-tubulin expression alone does not make cells targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site to inhibit tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06186986
disease_id_num_tar_ref
4837
drug_id_num_tar_ref
13053