gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific crosslinks GPC3 on tumor cells with 4-1BB on T/NK cells, delivering local 4-1BB costimulation; the engaged cytotoxic lymphocytes then kill GPC3+ cells via perforin/granzyme-mediated lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated cell-surface heparan sulfate proteoglycan on GPC3+ tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427941
disease_id_num_tar_ref
4840
drug_id_num_tar_ref
13062