gene_symbol
TNFRSF9
hgnc_id
HGNC:11924
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
BGB-B2033 binds 4-1BB on T/NK cells and GPC3 on tumor cells to deliver 4-1BB costimulation, activating cytotoxic lymphocytes that kill GPC3+ tumor cells; 4-1BB–expressing cells themselves are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Costimulatory receptor on activated T cells and NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427941
disease_id_num_tar_ref
4840
drug_id_num_tar_ref
13062