gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR engagement of GPC3 on target cells activates T-cell CD3ΞΆ/co-stimulatory signaling, forming an immunologic synapse and inducing cytolysis via perforin/granzyme release (and death-receptor pathways), killing GPC3-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05926726
disease_id_num_tar_ref
4841
drug_id_num_tar_ref
13064