gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds Trop-2, is internalized, and releases SN-38, which inhibits topoisomerase I, causing DNA damage, cell-cycle arrest, and apoptosis in Trop-2–expressing cells; membrane-permeable SN-38 can also cause a bystander effect.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glycoprotein overexpressed on many epithelial tumors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06966141
disease_id_num_tar_ref
4864
drug_id_num_tar_ref
13116