gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells engineered to recognize CD19 are activated via CD3ζ/costimulatory signaling and directly kill CD19+ cells through perforin–granzyme cytolysis and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen; targeted by dual CAR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06295549
disease_id_num_tar_ref
4867
drug_id_num_tar_ref
13123