gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Daratumumab binds CD38 on target cells and engages immune effectors via its Fc to mediate NK cell ADCC, complement-dependent cytotoxicity (CDC), and macrophage antibody-dependent cellular phagocytosis (ADCP), leading to lysis and clearance of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme on plasma cells and immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06042725
disease_id_num_tar_ref
4870
drug_id_num_tar_ref
13131