gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-mesothelin CAR T cells bind mesothelin and, via CD3zeta signaling, directly lyse target cells through perforin/granzyme-mediated cytotoxicity (with cytokine release).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface glycoprotein; HLA-independent CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06256055
disease_id_num_tar_ref
4872
drug_id_num_tar_ref
13135